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Docetaxel ebewe


Karcinogenní potenciál docetaxelu nebyl studován.

Bylo prokázáno, že docetaxel je mutagenní v mikronukleolárním testu in vitro a v testu aberace
chromozómů na buňkách CHO-K1 a v mikronukleolárním testu in vivo u myší. V Amesově testu ani ve
zkoušce genové mutace CHO/HGPRT však docetaxel mutagenitu neindukoval. Tyto výsledky jsou
v souladu s farmakologickou aktivitou docetaxelu.

Nežádoucí účinky na varlatech pozorované ve studiích toxicity u hlodavců naznačují, že docetaxel může
poškozovat samčí plodnost.

Docetaxel ebewe

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About project

A freely available non-commercial project for the purpose of laic drug comparisons at the level of interactions, side effects as well as drug prices and their alternatives

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