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Normosang


Po intravenózní infuzi heminu (3 mg/kg) byly farmakokinetické parametry (průměr ± SD) pozorované
u zdravých dobrovolníků a pacientů s porfyrií následující:


- C(o) .......................................................................................... 60,0 ± 17 μg/ml
- Eliminační poločas (t½)........................................................... 10,8 ± 1,6 hodin
- Celková plazmatická clearance................................................ 3,7 ± 1,2 ml/min
- Distribuční objem..................................................................... 3,4 ± 0,9 l

Po opakovaných infuzích se poločas hemu v organismu zvyšuje; po 4. infuzi se prodlouží na 18,1 hodiny.

Normosang

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A freely available non-commercial project for the purpose of laic drug comparisons at the level of interactions, side effects as well as drug prices and their alternatives

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