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Allopurinol aurobindo


Farmakoterapeutická skupina: přípravky inhibující tvorbu kyseliny močové, ATC kód: M04AA
Alopurinol je inhibitorem xanthinoxidázy. Alopurinol a jeho hlavní metabolit oxipurinol snižují hladinu
kyseliny močové v plasmě a v moči inhibicí xanthinoxidázy, což je enzym katalyzující oxidaci
hypoxanthinu na xanthin a xanthinu na kyselinu močovou. Vedle inhibice katabolismu purinů je u
některých, nikoli však všech hyperurikemických pacientů snížena biosyntéza purinů de novo, a to
zpětnovazebnou inhibicí hypoxanthinguaninfosforibosyltransferázy. Další metabolity alopurinolu
zahrnují alopurinol-ribosid a oxipurinol-7-ribosid.

Allopurinol aurobindo

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A freely available non-commercial project for the purpose of laic drug comparisons at the level of interactions, side effects as well as drug prices and their alternatives

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